![]() These were critically examined for methodology, results and interpretation. ![]() Database searches of Medline, Cochrane reviews, Google scholar and a hand search of cross-references identified forty-four original studies (twenty-three cross-sectional, seventeen prospective and four intervention) in adults and children, as well as six reviews. Since ongoing evaluation of this issue is important, the present systematic review re-examined the evidence from epidemiological studies and interventions, up to July 2008. Sugar-sweetened soft drinks (SSD) are a special target of many obesity-prevention strategies, yet critical reviews tend to be more cautious regarding the aetiological role of SSD in promoting excess body weight. From the findings of this study, it can be concluded that high intake of regular coke and coke zero can predispose one to some diseases, notably organ failure, diabetes mellitus and atherosclerosis. ![]() Abnormal lipid profile parameters gives an indication of predisposure to cardiovascular diseases such as atherosclerosis. Blood glucose concentration is a marker of diabetes mellitus while a rise in the activities of AST and ALT in the bloodstream gives an indication of failure of vital organs such as the heart and liver. Also both regular coke and coke zero showed a decrease in serum high density lipoprotein cholesterol concentration (p 0.05) on serum ALT activity and triglycerides. Results obtained showed that regular coke fed group exhibited significantly high blood glucose concentration (p 0.05). Different groups of the human subjects were fed Eva premium table water (330ml), regular coke (330ml) or coke zero (330ml) each day for 4 days. ![]() Regular coke and Coke zero were investigated for possible effects on blood glucose concentration, serum lipid profile and activities of serum aminotransferases (AST and ALT) of healthy human subjects.
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